Zuschrift

NIR‐II Fluorescent Self‐Assembled Peptide Nanochain for Ultrasensitive Detection of Peritoneal Metastasis

Qiuxiang Wen

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Yejun Zhang

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Dr. Chunyan Li

Corresponding Author

E-mail address: [email protected]

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Sisi Ling

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Xiaohu Yang

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Dr. Guangcun Chen

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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Dr. Yang Yang

Corresponding Author

E-mail address: [email protected]

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University, Shanghai, 200430 China

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Prof. Qiangbin Wang

Corresponding Author

E-mail address: [email protected]

School of Nano Technology and Nano Bionics, University of Science and Technology of China, Hefei, 230026 P. R. China

CAS Key Laboratory of Nano-Bio Interface, Division of Nanobiomedicine andi-Lab, CAS Center for Excellence in Brain Science, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China

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First published: 04 June 2019

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Citations: 2

Abstract

Fluorescence‐guided cytoreductive surgery is one of the most promising approaches for facile elimination of tumors in situ, thereby improving prognosis. Reported herein is a simple strategy to construct a novel chainlike NIR‐II nanoprobe (APP‐Ag2S‐RGD) by self‐assembly of an amphiphilic peptide (APP) into a nanochain with subsequent chemical crosslinking of NIR‐II Ag2S QDs and the tumor‐targeting RGD peptide. This probe exhibits higher capability for cancer cell detection compared with that of RGD‐functionalized Ag2S QDs (Ag2S‐RGD) at the same concentration. Upon intraperitoneal injection, superior tumor‐to‐normal tissue signal ratio is achieved and non‐vascularized tiny tumor metastatic foci as small as about 0.2 mm in diameter could be facilely eliminated under NIR‐II fluorescent imaging guidance. These results clearly indicate the potential of this probe for fluorescence‐guided tumor staging, preoperative diagnosis, and intraoperative navigation.

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